Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | FAAH | O00519 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ESRRG | P62508 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315116 | 0.82 | LMNA (0.76) | NPC1RAB9ASMN1; SMN2MAPK1FAAH | |
| SCHEMBL13234463 | 0.82 | RAB9A (0.64) | NPC1RAB9AMAPT | |
| SCHEMBL16486106 | 0.78 | FAAH (0.95) | NPC1RAB9ASMN1; SMN2MAPK1FAAH | |
| SCHEMBL17663699 | 0.77 | ALDH1A1 (0.54) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL18407361 | 0.76 | RAB9A (0.68) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL23862470 | 0.75 | LMNA (0.73) | NPC1RAB9ASMN1; SMN2LMNAESRRG | |
| SCHEMBL1474855 | 0.74 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPK1FAAH | |
| SCHEMBL17652827 | 0.73 | FAAH (0.84) | NPC1RAB9ASMN1; SMN2FAAHALDH1A1 | |
| SCHEMBL4284349 | 0.73 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2FAAHALDH1A1 | |
| SCHEMBL17660276 | 0.73 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |
| WO-2007067710-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS FOR MODULATING TRPV1 | AMPHORA DISCOVERY CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |