Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 5/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.40 |
| ▸ | UBE2I | P63279 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | APAF1 | O14727 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824579 | 0.77 | KDM4E (0.63) | KDM4EGAAPARP1ADORA1ADORA2A | |
| SCHEMBL14243195 | 0.74 | KDM4E (0.59) | KDM4EGAAPARP1ADORA1ADORA2A | |
| SCHEMBL5313894 | 0.74 | KDM4E (0.59) | KDM4EGAAPARP1CDC25BSAE1 | |
| SCHEMBL392734 | 0.74 | GAA (0.59) | KDM4EGAAPARP1ADORA1CDC25B | |
| SCHEMBL5313969 | 0.72 | ROCK2 (0.52) | PARP1 | |
| SCHEMBL741856 | 0.71 | AXL (0.59) | KDM4EGAACDC25BTDP2CASP6 | |
| SCHEMBL29488099 | 0.71 | KDM4E (1.00) | KDM4EGAAPARP1CDC25BSAE1 | |
| SCHEMBL824574 | 0.71 | KDM4E (1.00) | KDM4EGAAPARP1CDC25BSAE1 | |
| SCHEMBL25070895 | 0.70 | KDM4E (0.57) | KDM4EGAAPARP1ALDH1A1HPGD | |
| SCHEMBL3277310 | 0.67 | HSD17B10 (0.46) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053352-A2 | PYRROLOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099911-A1 | Pyrroloquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | KDM4E 3529/4885GAA 3571/4885PARP1 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.