Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953743 | 0.80 | PIK3CD (0.40) | HSD17B10KDM4EBRAFDAOMETAP2 | |
| SCHEMBL7070839 | 0.79 | KDM4E (0.50) | HSD17B10KDM4EBRAFDAOMETAP2 | |
| SCHEMBL8691865 | 0.76 | KDM4E (0.43) | HSD17B10KDM4EBRAFDAOMETAP2 | |
| SCHEMBL17142230 | 0.76 | KDM4E (0.43) | HSD17B10KDM4EBRAFDAOMETAP2 | |
| SCHEMBL3069941 | 0.76 | PIK3CD (0.47) | HSD17B10KDM4EDAOPARP15PARP10 | |
| SCHEMBL438637 | 0.75 | AR (0.47) | HSD17B10KDM4EBRAFPARP15PARP10 | |
| SCHEMBL7072330 | 0.75 | BRAF (0.58) | HSD17B10KDM4EBRAFTDP1PIK3CD | |
| SCHEMBL6955664 | 0.75 | IP6K1 (0.43) | KDM4EPIK3CD | |
| SCHEMBL5312181 | 0.74 | KDM4E (0.40) | KDM4EDAOTDP1NPC1POLB | |
| SCHEMBL11262249 | 0.73 | PIK3CD (0.36) | HSD17B10KDM4EBRAFPARP15PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448715-A | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein | UNIVERSITY OF MIAMI (US) | 1984-05-15 | — | — | US | claimed |
| EP-0078703-A2 | New tagged pyroglu-l-phe-l-arg derivatives, substrates and assays for kallikrein | UNIVERSITY OF MIAMI (US) | 1983-05-11 | — | — | EP | claimed |
| US-7700304-B2 | Methods of screening disorders related to apoE | THE J. DAVID GLADSTONE INSTITUTES (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1443816-B1 | METHODS OF TREATING DISORDERS RELATED TO APOE | DAVID GLADSTONE INST (US) | 2008-06-11 | — | — | EP | disclosed |
| US-7108988-B2 | Methods of identifying agents for inhibiting lentivirus replication | THE J. DAVID GLADSTONE INSTITUTES (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040268423-A1 | Methods of treating disorders related to apoE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-12-30 | — | — | US | disclosed |
| US-6787519-B2 | REDUCING NEURONAL TANGLES IN ALZHEMIER'S PATIENTS; OBTAIN HUMAN, ADMINISTER MODULATOR, MONITOR DEVELOPMENT OF NEURONAL TANGLES IN, REDUCTION IN NEURONAL TANGLES INDICATES MODULATOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-09-07 | — | — | US | disclosed |
| US-20040009909-A1 | Methods for inhibiting lentivirus replication | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-01-15 | — | — | US | disclosed |
| US-20020147999-A1 | Methods of treating disorders related to apoE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-10-10 | — | — | US | disclosed |
| US-6235494-B1 | USING CHELATE COMPOUND | THE SCRIPPS RESEARCH INSTITUTE | 2001-05-22 | — | — | US | disclosed |
| US-4448715-A | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein | UNIVERSITY OF MIAMI (US) | 1984-05-15 | — | — | US | disclosed |
| EP-0078703-A2 | New tagged pyroglu-l-phe-l-arg derivatives, substrates and assays for kallikrein | UNIVERSITY OF MIAMI (US) | 1983-05-11 | — | — | EP | disclosed |