Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30936310 | 0.75 | DRD4 (0.45) | KDM4ETSHRDRD4DRD2GRM5 | |
| SCHEMBL29995016 | 0.74 | GRM1 (0.36) | GRM1 | |
| SCHEMBL29995220 | 0.74 | KDM4E (0.42) | KDM4EMAPTDRD4DRD2GRM5 | |
| SCHEMBL24163505 | 0.74 | KDM4E (0.38) | KDM4ETSHRDRD4DRD2GRM5 | |
| SCHEMBL27860451 | 0.73 | KDM4E (0.39) | KDM4EMAPTTSHRDRD4DRD2 | |
| SCHEMBL7789812 | 0.73 | ALDH1A1 (0.41) | KDM4EMAPTTSHRSMN1; SMN2KMT2A | |
| SCHEMBL29958355 | 0.73 | — | — | |
| SCHEMBL1238592 | 0.73 | MGLL (0.37) | — | |
| SCHEMBL9276285 | 0.73 | MGLL (0.37) | — | |
| SCHEMBL9276325 | 0.73 | KEAP1 (0.41) | KDM4EMAPTSMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869039-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB Pharmco Puerto Rico Inc. (PR) | 2007-12-26 | — | — | EP | claimed |
| WO-2006108689-A2 | PROCESS FOR PREPARING BICYCLIC COMPOUNDS | SB PHARMCO PUERTO RICO INC (US) | 2006-10-19 | — | — | WO | claimed |
| EP-3083573-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC (US) | 2024-08-07 | — | — | EP | disclosed |