Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26806373 | 0.85 | ADRB1 (0.42) | ALDH1A1SMN1; SMN2HPGDADRB1KMT2A | |
| SCHEMBL9276325 | 0.77 | KEAP1 (0.41) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9276285 | 0.77 | MGLL (0.37) | MGLL | |
| SCHEMBL28000779 | 0.77 | ADRB1 (0.40) | ALDH1A1ADRB1KMT2AMEN1MGLL | |
| SCHEMBL29958355 | 0.77 | — | — | |
| SCHEMBL28406341 | 0.77 | GAA (0.36) | ALDH1A1SMN1; SMN2HPGDKMT2AMAPT | |
| SCHEMBL1238592 | 0.77 | MGLL (0.37) | MGLL | |
| SCHEMBL28211992 | 0.77 | FAAH (0.42) | ALDH1A1HPGDMAPTMGLLTSHR | |
| SCHEMBL3319952 | 0.74 | HSD17B10 (0.42) | ALDH1A1HPGDKMT2AMAPTMEN1 | |
| SCHEMBL5314044 | 0.73 | KDM4E (0.37) | ALDH1A1SMN1; SMN2HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010020013-A1 | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp | GUILFORD PHARMACEUTICALS, INC. | 2001-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020013-A1 | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp | PARP3, PARP1, PARP2 | ALDH1A1 373/4885SMN1; SMN2 2861/4885HPGD 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.