Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314383 | 0.87 | CCR1 (0.39) | CCR5POLBNSD2MEN1KMT2A | |
| SCHEMBL5319745 | 0.85 | KMT2A (0.43) | CCR5POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5316681 | 0.83 | POLB (0.40) | POLBKDM4EALDH1A1HTT | |
| SCHEMBL5317628 | 0.82 | NSD2 (0.41) | CCR5POLBNSD2MEN1KMT2A | |
| SCHEMBL5320812 | 0.77 | NSD2 (0.42) | CCR5POLBSLC6A2SLC6A4NSD2 | |
| SCHEMBL5317011 | 0.77 | KCNH2 (0.47) | MEN1 | |
| SCHEMBL5316954 | 0.72 | POLB (0.44) | POLBKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL2967576 | 0.71 | KCNH2 (0.47) | — | |
| SCHEMBL5315901 | 0.70 | DRD2 (0.49) | POLBKDM4EMEN1KMT2AGAA | |
| SCHEMBL5317641 | 0.69 | MEN1 (0.42) | CCR5NSD2MEN1KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |