Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17965952 | 0.74 | PGR (0.57) | MEN1KMT2AKCNH2ALDH1A1POLB | |
| SCHEMBL531314 | 0.73 | KDM4C (0.46) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL19349131 | 0.72 | MEN1 (0.61) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL1516345 | 0.72 | LMNA (0.47) | MEN1KMT2ASLC6A9SLC6A5KCNH2 | |
| SCHEMBL531388 | 0.71 | KMT2A (0.49) | MEN1KMT2AKCNH2ALDH1A1POLB | |
| SCHEMBL532486 | 0.71 | KMT2A (0.49) | MEN1KMT2AKCNH2ALDH1A1POLB | |
| SCHEMBL531457 | 0.71 | PLA2G4A (0.48) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL15812249 | 0.71 | KMT2A (0.59) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL15670744 | 0.71 | KMT2A (0.59) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL1911566 | 0.70 | GRM2 (0.39) | SLC6A9SLC6A5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |