Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.53 |
| ▸ | DRD2 | P14416 | 11/20 | 0.53 |
| ▸ | HTR7 | P34969 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315427 | 0.90 | MEN1 (0.47) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5315301 | 0.90 | KCNH2 (0.48) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5316933 | 0.88 | KCNH2 (0.47) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5315901 | 0.87 | DRD2 (0.49) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5319103 | 0.87 | KCNH2 (0.49) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5319012 | 0.85 | KCNH2 (0.43) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5315724 | 0.85 | KCNH2 (0.56) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5316328 | 0.85 | KCNH2 (0.55) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5316196 | 0.84 | KCNH2 (0.48) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5315934 | 0.84 | MCHR1 (0.48) | HTR1ADRD2KCNH2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |