Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765443 | 0.83 | TRPA1 (0.48) | LMNATSHRALDH1A1CFTRHSD17B10 | |
| SCHEMBL5745460 | 0.82 | NR4A1 (0.44) | TSHRALDH1A1HSD17B10TRPA1NR4A2 | |
| SCHEMBL70429 | 0.78 | LMNA (0.59) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL10357490 | 0.72 | LMNA (0.37) | LMNATSHRALDH1A1CFTRHSD17B10 | |
| SCHEMBL3230050 | 0.71 | NR4A2 (0.53) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL19082604 | 0.71 | KDM4E (0.50) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL19082607 | 0.71 | KDM4E (0.50) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL29434198 | 0.70 | BRD4 (0.59) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL70381 | 0.70 | BRD4 (0.59) | LMNATSHRBRD4ALDH1A1CFTR | |
| SCHEMBL19212289 | 0.70 | TRPA1 (0.47) | LMNATSHRALDH1A1CFTRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853578-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006088716-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |