Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ME2 | P23368 | 1/20 | 0.31 |
| ▸ | ME1 | P48163 | 1/20 | 0.31 |
| ▸ | ME3 | Q16798 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19026286 | 0.74 | KDM4E (0.38) | LMNAKDM4EADORA3ARCYP19A1 | |
| SCHEMBL11380880 | 0.65 | RET (0.40) | KDM4EADORA3ARCYP19A1MAOB | |
| SCHEMBL30891245 | 0.65 | RET (0.40) | KDM4EADORA3ARCYP19A1MAOB | |
| SCHEMBL13138773 | 0.65 | ABCG2 (0.39) | MAOBME2ME1ME3 | |
| SCHEMBL8587452 | 0.64 | EDNRB (0.30) | — | |
| SCHEMBL5100128 | 0.63 | KDM4E (0.30) | KDM4E | |
| SCHEMBL9411729 | 0.62 | EDNRB (0.31) | — | |
| SCHEMBL8030421 | 0.62 | ALDH1A1 (0.34) | KDM4EADORA3ARCYP19A1MAOB | |
| SCHEMBL27564813 | 0.62 | LMNA (0.37) | LMNAKDM4EHSD17B10 | |
| SCHEMBL14124733 | 0.61 | ME2 (0.56) | LMNAMAOBME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007019080-A2 | TRICYCLIC BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| EP-1651592-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014517-A2 | NOVEL DIBENZO[B,F]OXEPINE-10-CARBOXAMIDES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2005-02-17 | — | — | WO | disclosed |