SCHEMBL5316082

SCHEMBL5316082

COc1ccc(Sc2cc(C)ccc2C)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 2/20 0.52
HTR3A P46098 2/20 0.52
ACHE P22303 1/20 0.48
ALDH1A1 P00352 6/20 0.48
MAPT P10636 4/20 0.48
JAK2 O60674 1/20 0.48
HPGD P15428 4/20 0.44
GAA P10253 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
ALOX15 P16050 1/20 0.44
MAPK1 P28482 1/20 0.44
HSD17B10 Q99714 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
IDO1 P14902 1/20 0.42
LMNA P02545 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
POLB P06746 1/20 0.42
AKR1B1 P15121 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8736422 0.89 ACHE (0.48) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL11601099 0.85 MAPT (0.55) HTR1AHTR3AALDH1A1MAPTJAK2
SCHEMBL3547996 0.79 HTR1A (0.53) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL810329 0.79 ALDH1A1 (0.55) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL3484650 0.78 ACHE (0.71) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL7545112 0.78 HTR1A (0.48) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL20591216 0.78 MEN1 (0.55) HTR1AHTR3AACHEALDH1A1MEN1
SCHEMBL8374153 0.78 MAPT (0.54) HTR1AHTR3AACHEALDH1A1MAPT
SCHEMBL9486714 0.77 ALDH1A1 (0.49) HTR1AHTR3AALDH1A1MAPTJAK2
SCHEMBL11947061 0.77 MAPT (0.49) HTR1AHTR3AALDH1A1MAPTJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007064869-A2 CATALYSTS FOR ARYL SULFIDE SYNTHESIS AND METHOD OF PRODUCING ARYL SULFIDES YALE UNIVERSITY (US) 2007-06-07 WO disclosed
WO-2007064869-A2 CATALYSTS FOR ARYL SULFIDE SYNTHESIS AND METHOD OF PRODUCING ARYL SULFIDES YALE UNIVERSITY (US) 2007-06-07 WO disclosed