SCHEMBL7436618

SCHEMBL7436618

Nc1c(Br)cc(C(=O)NCC2CN3CCN2CC3)c2c1OCCO2

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR4 Q13639 1/20 0.35
DRD2 P14416 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7433792 0.87 HTR4 (0.48) HTR4
Hydrochloric Acid SCHEMBL8870522 0.86 HTR4 (0.47) HTR4
SCHEMBL7436666 0.83 HTR4 (0.44) HTR4DRD2
SCHEMBL5318148 0.71 KDM4E (0.53) HTR4
SCHEMBL7434391 0.71 DRD2 (0.40) DRD2
Hydrochloric Acid SCHEMBL8871742 0.70 DRD2 (0.40) DRD2
SCHEMBL5318149 0.70 HTR4 (0.41) HTR4
SCHEMBL8048001 0.69 HTR4 (0.64) HTR4
SCHEMBL5316403 0.68 SMN1; SMN2 (0.44) HTR4
SCHEMBL17978312 0.66 HTR4 (0.46) HTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5663173-A CENTRAL NERVOUS SYSTEM DISORDERS, COGNITION ACTIVATORS, PYCHOSES, ANTIDEPRESSANTS AND EATING DISORDERS SYNTHELABO (FR) 1997-09-02 US claimed
EP-0748807-A1 Derivatives of N-(1,4-diazabicyclo(2.2.2)-oct-2-yl)methyl benzamide, their preparation and their therapeutical use SYNTHELABO (FR) 1996-12-18 EP claimed
US-5663173-A CENTRAL NERVOUS SYSTEM DISORDERS, COGNITION ACTIVATORS, PYCHOSES, ANTIDEPRESSANTS AND EATING DISORDERS SYNTHELABO (FR) 1997-09-02 US disclosed
EP-0748807-A1 Derivatives of N-(1,4-diazabicyclo(2.2.2)-oct-2-yl)methyl benzamide, their preparation and their therapeutical use SYNTHELABO (FR) 1996-12-18 EP disclosed