Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3099790 | 0.85 | RIPK1 (0.37) | ADRA2AADRA2CALDH1A1TAAR1RIPK1 | |
| SCHEMBL7654223 | 0.76 | RIPK1 (0.39) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL3627338 | 0.74 | THRB (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL16888402 | 0.74 | THRB (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL9870121 | 0.74 | ADRA2A (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL12262583 | 0.74 | THRB (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL11659192 | 0.74 | TSHR (0.39) | ALDH1A1DPP4F2RIPK1TSHR | |
| SCHEMBL11237759 | 0.74 | TSHR (0.39) | ADRA2ALMNAKDM4EALDH1A1RIPK1 | |
| SCHEMBL18257694 | 0.74 | THRB (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL11000837 | 0.74 | RIPK1 (0.39) | LMNAKDM4EALDH1A1RIPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007077140-A1 | HYDROXY-NOREPHEDRINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | BASF AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |
| WO-2007077140-A1 | HYDROXY-NOREPHEDRINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | BASF AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |