Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.65 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.63 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28298203 | 0.89 | CHRM2 (0.79) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL10526447 | 0.88 | SMN1; SMN2 (0.65) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10960151 | 0.87 | SMN1; SMN2 (0.64) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10526466 | 0.87 | SMN1; SMN2 (0.64) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL30573473 | 0.86 | CHRM2 (0.70) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10526013 | 0.86 | SMN1; SMN2 (0.62) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10527455 | 0.86 | SMN1; SMN2 (0.62) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| Hydrochloric Acid SCHEMBL10527215 | 0.86 | SMN1; SMN2 (0.62) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL5320057 | 0.85 | CHRM2 (0.65) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 | |
| SCHEMBL11225310 | 0.84 | CHRM2 (0.63) | CHRM2OPRK1CYP1A2SLC6A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4100285-A | VASODILATION | NIPPON SHINYAKU CO., LTD. (JP) | 1978-07-11 | — | — | US | claimed |
| US-12569480-B2 | Methods of treating fibrosis using compounds that promote glucose oxidation | IMBRIA PHARMACEUTICALS, INC. (US) | 2026-03-10 | — | — | US | disclosed |
| US-20260060978-A1 | METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE-BASED COMPOUNDS | IMBRIA PHARMACEUTICALS INC (US) | 2026-03-05 | — | — | US | disclosed |
| US-20250262310-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2025-08-21 | — | — | US | disclosed |
| US-12318453-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | IMBRIA PHARMACEUTICALS, INC. (US) | 2025-06-03 | — | — | US | disclosed |
| US-12318382-B2 | Methods of treating rheumatic diseases using trimetazidine-based compounds | IMBRIA PHARMACEUTICALS, INC. (US) | 2025-06-03 | — | — | US | disclosed |
| US-20240100173-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2024-03-28 | — | — | US | disclosed |
| US-11844840-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | IMBRIA PHARMACEUTICALS, INC. (US) | 2023-12-19 | — | — | US | disclosed |
| US-20230399300-A1 | METHODS OF SYNTHESIZING 2-[4-[(2,3,4-TRIMETHOXYPHENYL)METHYL] PIPERAZIN-1-YL]ETHYL PYRIDINE-3-CARBOXYLATE | IMBRIA PHARMACEUTICALS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-20230399300-A1 | METHODS OF SYNTHESIZING 2-[4-[(2,3,4-TRIMETHOXYPHENYL)METHYL] PIPERAZIN-1-YL]ETHYL PYRIDINE-3-CARBOXYLATE | IMBRIA PHARMACEUTICALS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-20200138963-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2020-05-07 | — | — | US | disclosed |
| CN-111093662-A | Compositions and methods for improving cardiometabolic efficiency | 安布里亚制药公司 | 2020-05-01 | — | — | CN | disclosed |
| WO-2020081361-A1 | METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE-BASED COMPOUNDS | IMBRIA PHARMACEUTICALS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
| WO-2020081361-A1 | METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE-BASED COMPOUNDS | IMBRIA PHARMACEUTICALS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
| US-10556013-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | IMBRIA PHARMACEUTICALS, INC. (US) | 2020-02-11 | — | — | US | disclosed |
| US-10556013-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | IMBRIA PHARMACEUTICALS, INC. (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190216936-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2019-07-18 | — | — | US | disclosed |
| US-20190216936-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2019-07-18 | — | — | US | disclosed |
| US-20180360975-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | IMBRIA PHARMACEUTICALS, INC. | 2018-12-20 | — | — | US | disclosed |
| WO-2007096251-A1 | INHIBITORS OF CPT IN THE CENTRAL NERVOUS SYSTEM AS ANTIDIABETIC AND/OR ANTI-OBESITY DRUGS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12318382-B2 | Methods of treating rheumatic diseases using trimetazidine-based compounds | TRIM4, HMGCR, FAH | CHRM2 1726/4885OPRK1 2681/4885CYP1A2 549/4885 |
| US-20250262310-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-10556013-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-20260060978-A1 | METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE-BASED COMPOUNDS | TNNT2, TNNC1, CPT1B | CHRM2 563/4885OPRK1 646/4885CYP1A2 1833/4885 |
| US-20180360975-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-20240100173-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-12318453-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-20200138963-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-12569480-B2 | Methods of treating fibrosis using compounds that promote glucose oxidation | CPT1B, PFKP, PTK2 | CHRM2 336/4885OPRK1 2831/4885CYP1A2 1263/4885 |
| US-11844840-B2 | Compositions and methods for increasing efficiency of cardiac metabolism | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
| US-20230399300-A1 | METHODS OF SYNTHESIZING 2-[4-[(2,3,4-TRIMETHOXYPHENYL)METHYL] PIPERAZIN-1-YL]ETHYL PYRIDINE-3-CARBOXYLATE | TET3, TET2, TET1 | CHRM2 3208/4885OPRK1 194/4885CYP1A2 139/4885 |
| US-20190216936-A1 | COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM | PC, PCK2, CPT1B | CHRM2 2914/4885OPRK1 4692/4885CYP1A2 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.