Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694869 | 0.79 | HTR2A (0.48) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL28720281 | 0.78 | KDM1A (0.47) | ALDH1A1MAOAMAOBKDM1AOPRM1 | |
| SCHEMBL2437772 | 0.75 | ALDH1A1 (0.38) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL4904161 | 0.72 | ALDH1A1 (0.56) | ALDH1A1OPRM1OPRL1GAAOPRD1 | |
| SCHEMBL4901657 | 0.72 | ALDH1A1 (0.56) | ALDH1A1OPRM1OPRL1GAAOPRD1 | |
| SCHEMBL9466350 | 0.71 | MAOA (0.47) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL25401977 | 0.71 | DPP4 (0.44) | ALDH1A1MAOAMAOBKDM1ACYP2A6 | |
| SCHEMBL18092829 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MAOAMAOBKDM1AOPRM1 | |
| SCHEMBL28914563 | 0.70 | OPRM1 (0.69) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL172979 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084314-A2 | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-07-26 | — | — | WO | disclosed |