SCHEMBL5324722

SCHEMBL5324722

CC(CCc1ccccc1)NC(=O)/C=C\C(=O)N1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR3 P29371 1/20 0.58
LMNA P02545 1/20 0.58
GAA P10253 1/20 0.58
HTT P42858 1/20 0.58
GPX4 P36969 2/20 0.56
ALDH1A1 P00352 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MAPT P10636 1/20 0.52
CACNA2D1 P54289 5/20 0.52
CACNB1 Q02641 5/20 0.52
CACNA1B Q00975 4/20 0.52
CACNA1G O43497 7/20 0.52
CACNA1C Q13936 3/20 0.50
CACNA1A O00555 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
MAPK1 P28482 1/20 0.49
CYP2C19 P33261 1/20 0.49
CNR1 P21554 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5326584 0.90 ALDH1A1 (0.59) TACR3LMNAGAAHTTGPX4
SCHEMBL5326872 0.80 TACR3 (0.59) TACR3GPX4ALDH1A1KDM4EMAPT
SCHEMBL5351830 0.80 TACR3 (0.59) TACR3GPX4ALDH1A1KDM4EMAPT
SCHEMBL5331579 0.78 CACNA1G (0.64) TACR3LMNAGPX4ALDH1A1KDM4E
SCHEMBL5330923 0.72 ALDH1A1 (0.74) LMNAGAAHTTALDH1A1CYP1A2
SCHEMBL5330928 0.72 ALDH1A1 (0.74) LMNAGAAHTTALDH1A1CYP1A2
SCHEMBL5326655 0.71 CACNA1C (0.54) HTTALDH1A1KDM4EMAPTCACNA2D1
SCHEMBL16769444 0.71 KMT2A (0.82) TACR3GPX4ALDH1A1CACNA2D1CACNB1
SCHEMBL13309468 0.71 KMT2A (0.82) TACR3GPX4ALDH1A1CACNA2D1CACNB1
SCHEMBL13309487 0.70 CACNA2D1 (0.67) TACR3GPX4CACNA2D1CACNB1CACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007142431-A1 NEW NON-PEPTIDE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) 2007-12-13 WO claimed
WO-2007142431-A1 NEW NON-PEPTIDE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) 2007-12-13 WO disclosed
WO-2007142431-A1 NEW NON-PEPTIDE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION (KR) 2007-12-13 WO disclosed