Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325791 | 0.89 | CYP3A4 (0.41) | PDE4APDE4BPDE4CPDE4DTHRA | |
| SCHEMBL5325834 | 0.81 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DTHRA | |
| SCHEMBL2170953 | 0.77 | TTR (0.44) | THRATHRBMEN1KMT2A | |
| SCHEMBL5326880 | 0.76 | RORC (0.38) | THRBMEN1KMT2APOLBGAA | |
| SCHEMBL5333107 | 0.74 | THRB (0.50) | THRATHRBMEN1KMT2ACYP3A4 | |
| SCHEMBL16495779 | 0.72 | ALDH1A1 (0.52) | THRATHRBMEN1KMT2APOLB | |
| SCHEMBL16495780 | 0.72 | ALDH1A1 (0.52) | THRATHRBMEN1KMT2APOLB | |
| SCHEMBL5325788 | 0.69 | THRB (0.40) | PDE4APDE4BPDE4CPDE4DTHRA | |
| SCHEMBL11288852 | 0.68 | LTA4H (0.58) | — | |
| SCHEMBL18932876 | 0.68 | THRB (0.45) | THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007132475-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2007-11-22 | — | — | WO | claimed |
| WO-2007132475-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2007-11-22 | — | — | WO | disclosed |