Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | QPCT | Q16769 | 1/20 | 0.61 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.61 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.61 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14027194 | 0.83 | TBXAS1 (0.62) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL30022856 | 0.83 | CYP11B1 (0.65) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL30023445 | 0.81 | TBXAS1 (0.66) | CYP11B1CYP19A1TBXAS1KMT2A | |
| SCHEMBL9271695 | 0.79 | HMOX1 (0.41) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL30023008 | 0.78 | ALDH1A1 (0.50) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL5803076 | 0.77 | TSHR (0.58) | POLBLTA4H | |
| SCHEMBL10649611 | 0.77 | POLB (0.56) | CYP1A2CYP3A4CYP2D6TBXAS1POLB | |
| SCHEMBL10725247 | 0.77 | POLB (0.56) | CYP1A2CYP3A4CYP2D6TBXAS1POLB | |
| Benzylimidazole SCHEMBL414 | 0.76 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 | |
| SCHEMBL22063900 | 0.76 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP19A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160313-A | 2-phenylimidazole [1,2-a ] pyridine compound, composition containing same and application of two compounds | 中国药科大学 | 2022-10-11 | — | — | CN | disclosed |
| US-20160075724-A1 | CETP Inhibitors | MERCK SHARP & DOHME (US) | 2016-03-17 | — | — | US | disclosed |
| CN-104557757-A | CETP inhibitors | MERCK & CO INC | 2015-04-29 | — | — | CN | disclosed |
| CN-104447603-A | CETP inhibitors | MERCK SHARP & DOHME | 2015-03-25 | — | — | CN | disclosed |
| CN-102304096-B | CETP inhibitors | MERCK SHARP & DOHME | 2014-12-03 | — | — | CN | disclosed |
| CN-102311401-B | CETP inhibitors | MERCK & CO INC | 2014-12-03 | — | — | CN | disclosed |
| US-20140221383-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8735435-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-27 | — | — | US | disclosed |
| EP-1765793-B1 | ANACETRAPIB AND OTHER CETP INHIBITPRS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0341481-A1 | N-heterocyclic alcohol derivatives | E.R. Squibb & Sons, Inc. (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0337295-A2 | Renin-inhibiting N-heterocyclic dipeptides | E.R. Squibb & Sons, Inc. (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0237929-A1 | 3,5-Disubstituted pyrocatechol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-23 | — | — | EP | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |
| US-4528195-A | Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations | THOROGOOD PETER B (GB) | 1985-07-09 | — | — | US | disclosed |
| EP-0003560-B1 | IMIDAZOLE DERIVATIVES AND SALTS THEREOF, THEIR SYNTHESIS, AND PHARMACEUTICAL FORMULATIONS | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |
| US-4416895-A | ANTICOAGULANTS, ANTISHOCK AGENTS | BURROUGHS WELLCOME CO. (US) | 1983-11-22 | — | — | US | disclosed |
| EP-0003560-A2 | Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-08-22 | — | — | EP | disclosed |
| US-4152441-A | Analgesic imidazolemethanols | GIST-BROCADES N.V. (NL) | 1979-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221383-A1 | CETP INHIBITORS | CETP, APOB, MTTP | CYP11B1 370/4885CYP11B2 569/4885CYP19A1 543/4885 |
| US-20160075724-A1 | CETP Inhibitors | CETP, APOB, MTTP | CYP11B1 370/4885CYP11B2 569/4885CYP19A1 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.