Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.46 |
| ▸ | BCR | P11274 | 10/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327745 | 0.81 | MAPT (0.52) | ABL1BCRMAPTALDH1A1 | |
| SCHEMBL5326485 | 0.71 | ALDH1A1 (0.48) | ABL1BCRMAPTALDH1A1 | |
| SCHEMBL5296074 | 0.69 | HRH3 (0.50) | ABL1BCRHRH3JAK2 | |
| SCHEMBL5327112 | 0.69 | GHSR (0.49) | — | |
| SCHEMBL6152664 | 0.67 | F10 (0.65) | MAPTALDH1A1 | |
| SCHEMBL5326524 | 0.65 | L3MBTL1 (0.54) | MAPTALDH1A1 | |
| SCHEMBL5322343 | 0.64 | ALDH1A1 (0.53) | MAPTALDH1A1 | |
| SCHEMBL29431362 | 0.64 | ABL1 (0.48) | ABL1BCRMAPK8MAPK10 | |
| SCHEMBL22314749 | 0.64 | ABL1 (0.48) | ABL1BCRMAPK8MAPK10 | |
| SCHEMBL12773377 | 0.63 | HRH3 (0.53) | HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008145-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | claimed |