Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.42 |
| ▸ | PPARD | Q03181 | 7/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5292147 | 0.89 | CYP11B2 (0.41) | KIF11CYP11B2CYP11B1PPARDPPARA | |
| SCHEMBL5299485 | 0.88 | PDGFRB (0.38) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL5280752 | 0.87 | KMO (0.39) | ALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL5281477 | 0.83 | PDGFRB (0.43) | ALDH1A1L3MBTL1MEN1KMT2AHPGD | |
| SCHEMBL5126871 | 0.83 | ALDH1A1 (0.46) | KIF11CYP11B2CYP11B1ALDH1A1L3MBTL1 | |
| SCHEMBL5280707 | 0.81 | KMT2A (0.40) | ALDH1A1L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL5282908 | 0.81 | S1PR1 (0.41) | PPARDPPARAALDH1A1L3MBTL1MAPT | |
| SCHEMBL5298454 | 0.78 | CYP1A2 (0.39) | ALDH1A1MAPTKDM4E | |
| SCHEMBL5285137 | 0.77 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL5120286 | 0.76 | ALDH1A1 (0.53) | KIF11CYP11B2CYP11B1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866289-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097220-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-09-21 | — | — | WO | disclosed |