Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503768 | 0.75 | SLC7A5 (0.71) | CYP1A2SLC7A5PTGS1PTGS2LMNA | |
| SCHEMBL1410416 | 0.75 | TBXAS1 (0.53) | PPARGPPARATSHRPTGS1PTGS2 | |
| SCHEMBL296278 | 0.75 | SLC7A5 (0.71) | CYP1A2SLC7A5PTGS1PTGS2LMNA | |
| SCHEMBL216414 | 0.75 | SLC7A5 (0.71) | CYP1A2SLC7A5PTGS1PTGS2LMNA | |
| SCHEMBL4555875 | 0.75 | KDM6B (0.66) | PPARGCYP1A2SLC7A5TSHRPTGS1 | |
| SCHEMBL14540276 | 0.73 | SLC1A3 (0.61) | PPARGPPARACYP1A2SLC7A5TSHR | |
| SCHEMBL498838 | 0.73 | TSHR (0.48) | PPARGPPARACYP1A2TSHR | |
| SCHEMBL1268578 | 0.72 | SLC1A3 (0.52) | PPARGPPARACYP1A2HTR2A | |
| Oxalic Acid SCHEMBL30089202 | 0.71 | TSHR (0.58) | PPARGPPARATSHR | |
| SCHEMBL2209126 | 0.70 | SRC (0.56) | PPARGPPARATSHRPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002469-A2 | THERAPEUTIC COMPOSITIONS AND METHODS USING TRANSFORMING GROWTH FACTOR-BETA MIMICS | BHATNAGAR RAJENDRA S (US) | 2007-01-04 | — | — | WO | disclosed |