Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 11/20 | 0.41 |
| ▸ | ADRA1B known ✓ | P35368 | 9/20 | 0.41 |
| ▸ | ADRA1D known ✓ | P25100 | 9/20 | 0.41 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525606 | 0.94 | ADRA1A (0.42) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL4533798 | 0.94 | ADRA1A (0.42) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Succinic Acid SCHEMBL5328382 | 0.93 | ADRA1D (0.41) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Cadaverine Tartrate SCHEMBL5332836 | 0.93 | DRD2 (0.44) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Maleic Acid SCHEMBL5330865 | 0.92 | ADRA1A (0.41) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Fumaric Acid SCHEMBL5329649 | 0.92 | ADRA1A (0.41) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Phosphoric Acid SCHEMBL5333270 | 0.91 | ADRA1A (0.42) | ADRA1AADRA1BADRA1DDRD2HTR1A | |
| Cadaverine Tartrate SCHEMBL5295564 | 0.89 | HTR1A (0.41) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Cadaverine Tartrate SCHEMBL5326142 | 0.89 | DRD2 (0.41) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL14541002 | 0.87 | DRD2 (0.48) | ADRA1AADRA1BADRA1DDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026041-A2 | COMPUESTOS QUINÓNICOS ANTITUMORALES Y SUS DERIVADOS, PROCEDIMIENTO DE OBTENCIÓN Y SUS APLICACIONES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2007-03-08 | — | — | WO | claimed |
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |