Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807946 | 0.78 | PTGS2 (0.35) | ARKDM4EALDH1A1HPGDGAA | |
| SCHEMBL9015231 | 0.78 | PTGS2 (0.35) | KDM4EALDH1A1TSHRHTTMAPT | |
| SCHEMBL8802718 | 0.76 | KDM4E (0.38) | ARKDM4EALDH1A1HPGDGAA | |
| SCHEMBL375607 | 0.70 | NOTUM (0.46) | ARKDM4EALDH1A1HPGDGAA | |
| SCHEMBL8800614 | 0.68 | PTGS2 (0.35) | KDM4EALDH1A1TSHRHTTMAPT | |
| SCHEMBL16339341 | 0.67 | AR (0.58) | ARTSHRHSD17B10 | |
| SCHEMBL9019307 | 0.66 | GPR84 (0.45) | ALDH1A1TSHRHSD17B10GPR84 | |
| SCHEMBL8652250 | 0.66 | TSHR (0.44) | KDM4EALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL10674805 | 0.65 | GAA (0.37) | ARKDM4EALDH1A1HPGDGAA | |
| SCHEMBL8450876 | 0.64 | TSHR (0.44) | ARALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102746208-A | Economic preparation method of 4-bromine-2-aryl-5-trifluoromethyl-1H-pyrrole-3-nitrile | XINYI YONGLONG CHEMICAL CO LTD | 2012-10-24 | — | — | CN | claimed |
| CN-1193988-C | Preparation of 2-aryl-5-(trifluoride) pyrrole-3-nitrile and its use and preparation of its intermediate thereof | JIANGSU PESTICDIDE INST CO LTD (CN) | 2005-03-23 | — | — | CN | claimed |
| CN-1439634-A | Preparation of 2-aryl-5-(trifluoride) pyrrole-3-nitrile and its use and preparation of its intermediate thereof | JIANGSU PESTICIDE INST CO LTD (CN) | 2003-09-03 | — | — | CN | claimed |
| EP-0531702-B1 | Process for the manufacture of insecticidal, nematicidal and acaricidal 2-aryl-3-subst. -5-(trifluoromethyl)pyrrole compounds from N-(subst. benzyl)-2,2,2-trifluoroacetimidoyl chloride compounds | BASF AG (DE) | 2001-05-30 | — | — | EP | claimed |
| US-5537260-A | Catadioptric optical reduction system with high numerical aperture | SVG LITHOGRAPHY SYSTEMS, INC. (US) | 1996-07-16 | — | — | US | claimed |
| JP-6279402-A | — | — | None | — | — | JP | disclosed |
| CN-102746208-A | Economic preparation method of 4-bromine-2-aryl-5-trifluoromethyl-1H-pyrrole-3-nitrile | XINYI YONGLONG CHEMICAL CO LTD | 2012-10-24 | — | — | CN | disclosed |
| EP-0816347-B1 | Ammonium oxazole- and amino oxazolium intermediates, methods for their preparation and their use in the manufacture of insecticidal, acaricidal and nematocidal arylpyrrole derivatives | BASF AG (DE) | 2007-06-20 | — | — | EP | disclosed |
| CN-1193988-C | Preparation of 2-aryl-5-(trifluoride) pyrrole-3-nitrile and its use and preparation of its intermediate thereof | JIANGSU PESTICDIDE INST CO LTD (CN) | 2005-03-23 | — | — | CN | disclosed |
| CN-1439634-A | Preparation of 2-aryl-5-(trifluoride) pyrrole-3-nitrile and its use and preparation of its intermediate thereof | JIANGSU PESTICIDE INST CO LTD (CN) | 2003-09-03 | — | — | CN | disclosed |
| EP-0826667-B1 | 2 Aryl 5 (trifluoromethyl) 2 pyrroline compounds and process for the manufacture of insecticidal, 2 aryl 1 (alkoxymethyl) 4 halo 5 (trifluoromethyl) pyrroles | BASF AG (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0713868-B1 | Process for the manufacture of insecticidal arylpyrroles via oxazole amine intermediates | BASF AG (DE) | 2002-01-16 | — | — | EP | disclosed |
| US-5194630-A | Halogenation and etherification of 2-aryl-1-methyl-2-pyrroline | AMERICAN CYANAMID COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| CN-1063281-A | 2-aryl-5- (trifluoromethyl) -2-pyrroline compounds and process for preparing insecticide, 2-aryl-1- (alkoxymethyl) -4-halo-5- (trifluoromethyl) pyrrole | AMERICAN CYANAMID CO (US) | 1992-08-05 | — | — | CN | disclosed |
| EP-0492171-A1 | 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles | AMERICAN CYANAMID COMPANY (US) | 1992-07-01 | — | — | EP | disclosed |
| US-5010098-A | Arylpyrrole insecticidal acaricidal and nematicidal agents and methods for the preparation thereof | AMERICAN CYANAMID COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| US-4929634-A | ARYLPYRROLE COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 1990-05-29 | — | — | US | disclosed |
| EP-0358047-A2 | Method of controlling phytopathogenic fungi | AMERICAN CYANAMID COMPANY (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0347488-A1 | Arylpyrrole insecticidal acaricidal and nematicidal agents and method for the preparation thereof | AMERICAN CYANAMID COMPANY (US) | 1989-12-27 | — | — | EP | disclosed |
| EP-0312723-A2 | Method of and bait compositions for controlling mollusks | AMERICAN CYANAMID COMPANY (US) | 1989-04-26 | — | — | EP | disclosed |