Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015231 | 0.83 | PTGS2 (0.35) | PTGS2CYP3A4GPR84KDM4EALDH1A1 | |
| SCHEMBL8800614 | 0.72 | PTGS2 (0.35) | PTGS2CYP3A4GPR84KDM4EALDH1A1 | |
| SCHEMBL9277961 | 0.70 | GPR84 (0.41) | PTGS2CYP3A4GPR84KDM4EALDH1A1 | |
| SCHEMBL8800830 | 0.69 | HSD11B1 (0.32) | GPR84HSD11B1 | |
| SCHEMBL8802926 | 0.69 | GPR84 (0.44) | GPR84KDM4EALDH1A1GLAGAA | |
| SCHEMBL3962419 | 0.68 | HIF1A (0.49) | GPR84KMT2AHSD11B1 | |
| SCHEMBL11060653 | 0.68 | PTGS2 (0.35) | PTGS2CYP3A4GPR84KMT2A | |
| SCHEMBL11300744 | 0.66 | KMT2A (0.33) | CYP3A4GPR84KMT2A | |
| SCHEMBL8802342 | 0.64 | — | — | |
| SCHEMBL9267234 | 0.64 | S1PR1 (0.37) | CYP3A4KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481182-B1 | Bis- and tris(trifluoromethyl) arylpyrrole insecticidal and acaricidal agents | AMERICAN CYANAMID CO (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5281719-A | Reacting a methyl N-((trimethylsilyl)methyl)thiobenzimidate with 2,3-dichloro-hexafluorobutene to give a 2-aryl-3,4-bis-(trifluoromethyl)pyrrole and reacting this with a halogenating compound | AMERICAN CYANAMID COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| US-5229524-A | Bis-and tris (trifluoromethyl) arylpyrrole insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY (US) | 1993-07-20 | — | — | US | disclosed |
| US-5157047-A | Miticides | AMERICAN CYANAMID COMPANY (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0481182-A1 | Bis- and tris(trifluoromethyl) arylpyrrole insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY (US) | 1992-04-22 | — | — | EP | disclosed |