Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 7/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961026 | 0.94 | CHRM4 (0.62) | CHRM4HSD11B1TSHRCYP3A4CYP2C9 | |
| SCHEMBL5360560 | 0.87 | HSD11B1 (0.62) | CHRM4HSD11B1TSHRKMT2AALDH1A1 | |
| SCHEMBL5350376 | 0.87 | CHRM4 (0.63) | CHRM4TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3223609 | 0.85 | CHRM4 (0.57) | CHRM4HSD11B1TSHRLMNAMAPT | |
| SCHEMBL2963243 | 0.84 | CHRM4 (0.56) | CHRM4HSD11B1TSHRLMNAMAPT | |
| SCHEMBL2961967 | 0.84 | ALDH1A1 (0.61) | CHRM4HSD11B1LMNAMAPTKMT2A | |
| SCHEMBL3216764 | 0.84 | ALDH1A1 (0.64) | CHRM4HSD11B1TSHRLMNAMAPT | |
| SCHEMBL10723724 | 0.83 | CHRM4 (0.64) | CHRM4TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4555453 | 0.82 | TSHR (0.78) | CHRM4TSHRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL31684034 | 0.82 | TSHR (0.78) | CHRM4TSHRCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | claimed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |