Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961026 | 0.89 | CHRM4 (0.62) | ALDH1A1LMNASMN1; SMN2HSD17B10TSHR | |
| SCHEMBL3221923 | 0.86 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2HSD17B10TSHR | |
| SCHEMBL5331434 | 0.84 | CHRM4 (0.64) | ALDH1A1LMNASMN1; SMN2TSHRPKM | |
| SCHEMBL3223609 | 0.84 | CHRM4 (0.57) | LMNATSHRHSD11B1CHRM4MAPT | |
| SCHEMBL2963243 | 0.82 | CHRM4 (0.56) | ALDH1A1LMNASMN1; SMN2HSD17B10TSHR | |
| SCHEMBL2961967 | 0.82 | ALDH1A1 (0.61) | ALDH1A1LMNASMN1; SMN2PKMMAPK1 | |
| SCHEMBL10723724 | 0.82 | CHRM4 (0.64) | ALDH1A1LMNASMN1; SMN2TSHRPOLB | |
| SCHEMBL3212651 | 0.82 | HSD11B1 (0.67) | ALDH1A1SMN1; SMN2HSD11B1CHRM4KMT2A | |
| SCHEMBL3207442 | 0.79 | LMNA (0.74) | ALDH1A1LMNASMN1; SMN2HSD17B10TSHR | |
| SCHEMBL2959432 | 0.79 | CHRM4 (0.52) | ALDH1A1LMNASMN1; SMN2HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | ALDH1A1 116/4885LMNA 3748/4885SMN1; SMN2 3575/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 123/4885LMNA 3681/4885SMN1; SMN2 3686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.