Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PGK1 | P00558 | 1/20 | 0.46 |
| ▸ | PGK2 | P07205 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11378806 | 0.82 | AKR1C3 (0.46) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL5983777 | 0.82 | AKR1C3 (0.58) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL5983772 | 0.80 | AKR1C3 (0.81) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL5069158 | 0.80 | AKR1C3 (1.00) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL5983768 | 0.80 | AKR1C3 (0.74) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL8601137 | 0.78 | AKR1C3 (0.53) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL8779946 | 0.78 | AKR1C3 (0.71) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL11544092 | 0.77 | AKR1C3 (0.70) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL6932050 | 0.77 | AKR1C3 (0.70) | AKR1C3IDO1MAOBPGK1PGK2 | |
| SCHEMBL10766432 | 0.77 | AKR1C3 (0.70) | AKR1C3IDO1MAOBPGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235666-B2 | Sulfonation of 3-(hydroxymethyl)-5,5-diphenylimidazolidine-2,4-dione followed by phosphating in the presence of trisubstituted aliphatic amine base and a polar aprotic solvent; anticonvulsants, antiepileptic and antiarrhythmia agent | CILAG LTD. (CH) | 2007-06-26 | — | — | US | disclosed |
| US-20050272706-A1 | Process for the preparation of sodium fosphenytoin | CILAG, LTD. | 2005-12-08 | — | — | US | disclosed |
| EP-0131993-B1 | PHOSPHORYLATING AGENT; A PROCESS FOR THE PREPARATION THEREOF; A PROCESS FOR PHOSPHORYLATING AN ORGANIC HYDROXYL OR AMINE COMPOUND | Stichting Katholieke Universiteit (NL) | 1988-05-25 | — | — | EP | disclosed |
| US-4017615-A | ESPECIALLY USEFUL FOR ANTIINFLAMMATORY TOPICAL CORTICOIDS | SYNTEX CORPORATION (PM) | 1977-04-12 | — | — | US | disclosed |
| US-3962275-A | ANTIGONADOTROPIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272706-A1 | Process for the preparation of sodium fosphenytoin | FOS, DUSP5, DCPS | AKR1C3 1482/4885IDO1 3664/4885MAOB 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.