Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059778 | 0.80 | HPGD (0.66) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL9835629 | 0.79 | KEAP1 (0.56) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL9054541 | 0.77 | HPGD (0.67) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL7262812 | 0.77 | HPGD (0.67) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL10822866 | 0.76 | LMNA (0.59) | LMNAMAPTALDH1A1PSIP1TP53 | |
| SCHEMBL9034826 | 0.75 | HPGD (0.64) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL6295481 | 0.75 | HPGD (0.64) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL7988528 | 0.75 | HPGD (0.64) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL10683547 | 0.75 | HPGD (0.64) | HPGDLMNAHTTSMN1; SMN2MAPT | |
| SCHEMBL19303636 | 0.75 | HPGD (0.64) | HPGDLMNAHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |