SCHEMBL5334510

SCHEMBL5334510

CC(C)(C)[Si](C)(C)OCc1cc(-c2c(F)cccc2Cl)no1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 6/20 0.38
CHRNA4 P43681 6/20 0.38
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 3/20 0.36
POLB P06746 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
SCN9A Q15858 3/20 0.36
SMN1; SMN2 Q16637 4/20 0.36
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
HPGD P15428 1/20 0.36
STAT3 P40763 1/20 0.36
STAT1 P42224 1/20 0.36
ALDH1A1 P00352 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TP53 P04637 1/20 0.35
ALOX15 P16050 1/20 0.34
SCN5A Q14524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5335644 0.91 MAPT (0.40) MAPTL3MBTL1POLBTDP1SMN1; SMN2
SCHEMBL5802338 0.85 L3MBTL1 (0.38) MAPTL3MBTL1POLBTDP1SMN1; SMN2
SCHEMBL5331359 0.77 NPC1 (0.38) CHRNB2CHRNA4MAPTL3MBTL1POLB
SCHEMBL5309057 0.77 NOTUM (0.51) CHRNB2CHRNA4MAPTSMN1; SMN2RAB9A
SCHEMBL5327885 0.74 RAB9A (0.45) MAPTL3MBTL1POLBTDP1SMN1; SMN2
SCHEMBL17494714 0.74 KMT2A (0.47) L3MBTL1TDP1SCN9ASMN1; SMN2ALDH1A1
SCHEMBL6086455 0.72 L3MBTL1 (0.50) CHRNB2CHRNA4L3MBTL1SMN1; SMN2RAB9A
SCHEMBL5775508 0.72 CHRNB2 (0.46) CHRNB2CHRNA4MAPTL3MBTL1SMN1; SMN2
SCHEMBL5820381 0.71 CHRNB2 (0.37) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD
SCHEMBL5334515 0.69 CHRNB2 (0.38) CHRNB2CHRNA4MAPTSMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007034445-A2 NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY ACTELION PHARMACEUTICALS LTD (CH) 2007-03-29 WO disclosed
WO-2006064484-A1 AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2006-06-22 WO disclosed