Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334510 | 0.91 | CHRNB2 (0.38) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL5802338 | 0.81 | L3MBTL1 (0.38) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL5327885 | 0.79 | RAB9A (0.45) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL5331359 | 0.77 | NPC1 (0.38) | MAPTL3MBTL1TDP1POLBRAB9A | |
| SCHEMBL14591951 | 0.76 | MAPT (0.43) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL1313922 | 0.75 | NOTUM (0.44) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL5304332 | 0.73 | NOTUM (0.58) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL27788975 | 0.73 | NOTUM (0.62) | MAPTMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL3759539 | 0.71 | MEN1 (0.31) | MEN1KMT2A | |
| SCHEMBL30723709 | 0.70 | RAB9A (0.37) | MAPTMEN1KMT2AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |