Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.64 |
| ▸ | EDNRA | P25101 | 2/20 | 0.64 |
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.55 |
| ▸ | PPIA | P62937 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14484038 | 0.80 | PPIA (0.64) | PPIAHPGDALDH1A1MAPTADRA1A | |
| SCHEMBL5305344 | 0.80 | RORA (0.50) | PPIATSHRALDH1A1MAPTADRA1A | |
| SCHEMBL5349152 | 0.79 | EDNRA (0.64) | EDNRBEDNRAPPIATSHRALDH1A1 | |
| SCHEMBL7716873 | 0.78 | ALDH1A1 (0.54) | EDNRBEDNRAPPIAHPGDTSHR | |
| SCHEMBL356417 | 0.76 | MCL1 (0.54) | EDNRBEDNRAMCL1HPGDTSHR | |
| SCHEMBL7716759 | 0.76 | EDNRA (1.00) | EDNRBEDNRABRD4 | |
| SCHEMBL7221804 | 0.76 | EDNRA (1.00) | EDNRBEDNRABRD4 | |
| SCHEMBL6685980 | 0.74 | TSHR (0.71) | PPIATSHRALDH1A1MAPTADRA1A | |
| SCHEMBL356140 | 0.74 | MCL1 (0.58) | EDNRBEDNRAMCL1HPGDTSHR | |
| SCHEMBL20495825 | 0.73 | POLB (0.48) | PPIATSHRALDH1A1MAPTADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | EDNRB 396/4885EDNRA 609/4885BRD4 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.