Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | FBP1 | P09467 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | EDNRB | P24530 | 2/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.52 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL356140 | 0.81 | MCL1 (0.58) | MCL1FBP1TSHRHPGDEDNRB | |
| SCHEMBL3923771 | 0.80 | HSD11B1 (0.73) | TSHRHPGDEDNRBEDNRAPCTP | |
| SCHEMBL5334733 | 0.76 | EDNRB (0.64) | MCL1FBP1TSHRHPGDEDNRB | |
| SCHEMBL14403379 | 0.71 | MEN1 (0.62) | MCL1TSHRHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8356883 | 0.71 | SMN1; SMN2 (0.50) | MCL1TSHRHPGDKDM4EALDH1A1 | |
| SCHEMBL5348053 | 0.71 | ALPL (0.58) | MCL1FBP1HPGDEDNRBEDNRA | |
| SCHEMBL1378352 | 0.71 | MAPT (0.50) | MCL1FBP1TSHRHPGDEDNRB | |
| SCHEMBL9912021 | 0.70 | NOS3 (0.55) | TSHRHPGDPCTPKDM4EALDH1A1 | |
| SCHEMBL2372705 | 0.70 | MCL1 (0.62) | MCL1TSHRHPGDEDNRBEDNRA | |
| SCHEMBL1377855 | 0.70 | PDE4A (0.54) | PCTPKDM4EALDH1A1GAAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| EP-2190432-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | Protelogiecs, Ltd. (IL) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024980-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS LTD (IL) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009024980-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS LTD (IL) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PITHD1, PLPBP, UPP1 | MCL1 1307/4885FBP1 527/4885TSHR 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.