Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | EDNRB | P24530 | 2/20 | 0.56 |
| ▸ | EDNRA | P25101 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | FBP1 | P09467 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL356417 | 0.81 | MCL1 (0.54) | MCL1GAALMNATSHRHPGD | |
| SCHEMBL8356883 | 0.80 | SMN1; SMN2 (0.50) | MCL1GAATSHRHPGDHSD11B1 | |
| SCHEMBL29019103 | 0.77 | ALDH1A1 (0.62) | GAALMNATSHRHSD11B1ALDH1A1 | |
| SCHEMBL14018681 | 0.75 | MAPT (0.53) | LMNAEDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL8351640 | 0.74 | MCL1 (0.52) | MCL1GAATSHRHPGDALDH1A1 | |
| SCHEMBL5348053 | 0.74 | ALPL (0.58) | MCL1LMNAHPGDEDNRBEDNRA | |
| SCHEMBL10498943 | 0.74 | LMNA (0.43) | GAALMNATSHRHSD11B1ALDH1A1 | |
| SCHEMBL5334733 | 0.74 | EDNRB (0.64) | MCL1TSHRHPGDEDNRBEDNRA | |
| Hydrochloric Acid SCHEMBL10561364 | 0.73 | MCL1 (0.51) | MCL1GAATSHRHPGDALDH1A1 | |
| SCHEMBL2372705 | 0.73 | MCL1 (0.62) | MCL1GAATSHRHPGDEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS, LTD. (IL) | 2012-01-19 | — | — | US | disclosed |
| EP-2190432-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | Protelogiecs, Ltd. (IL) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024980-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS LTD (IL) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009024980-A2 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PROTEOLOGICS LTD (IL) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015967-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS | PITHD1, PLPBP, UPP1 | MCL1 1307/4885GAA 2302/4885LMNA 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.