Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.30 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031774 | 0.90 | LMNA (0.34) | HTTLMNATSHRCYP3A4OPRM1 | |
| SCHEMBL476025 | 0.90 | LMNA (0.34) | HTTLMNATSHRCYP3A4OPRM1 | |
| Hydrochloric Acid SCHEMBL5234106 | 0.88 | LMNA (0.33) | HTTLMNATSHROPRM1OPRL1 | |
| Cadaverine Tartrate SCHEMBL5328580 | 0.84 | TSHR (0.33) | HTTSMN1; SMN2LMNATSHRMAPT | |
| Maleic Acid SCHEMBL5326719 | 0.74 | HTT (0.31) | HTTSMN1; SMN2NPC1GAAPOLB | |
| Maleic Acid SCHEMBL5326717 | 0.74 | HTT (0.32) | HTTSMN1; SMN2NPC1GAALMNA | |
| Fumaric Acid SCHEMBL5326723 | 0.74 | HTT (0.32) | HTTSMN1; SMN2NPC1GAALMNA | |
| SCHEMBL6901500 | 0.65 | HSD11B1 (0.31) | — | |
| SCHEMBL2106696 | 0.65 | CCR2 (0.33) | HTT | |
| SCHEMBL2011171 | 0.65 | HSD11B1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | claimed |