Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329808 | 0.96 | HTR7 (0.53) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL5330830 | 0.78 | HTR7 (0.64) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL30296953 | 0.74 | ALDH1A1 (0.64) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL30305062 | 0.74 | HTR1A (0.61) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL29142480 | 0.74 | MEN1 (0.61) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL2795026 | 0.74 | HTR7 (0.63) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL13487703 | 0.74 | HTR7 (0.63) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL1828054 | 0.74 | HTR1A (0.61) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL155413 | 0.74 | ALDH1A1 (0.64) | HTR7HTR1ADRD3DRD2HTR2A | |
| SCHEMBL96852 | 0.74 | HTR7 (0.59) | HTR7HTR1ADRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007029156-A2 | ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | claimed |
| WO-2007029156-A2 | ISOINDOLEDIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-15 | — | — | WO | disclosed |