Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334515 | 0.91 | CHRNB2 (0.38) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL5327891 | 0.79 | MAPT (0.43) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL5331361 | 0.77 | CNR2 (0.38) | KMT2AMAPTMEN1ALDH1A1CHRNB2 | |
| SCHEMBL5332143 | 0.69 | GALR3 (0.34) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL23302623 | 0.68 | SMN1; SMN2 (0.47) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL10163467 | 0.68 | RAB9A (0.49) | KMT2AMAPTMEN1POLBALDH1A1 | |
| SCHEMBL2324549 | 0.67 | ALDH1A1 (0.33) | ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2332738 | 0.67 | NOTUM (0.35) | — | |
| SCHEMBL2326700 | 0.67 | — | — | |
| SCHEMBL5465268 | 0.66 | ALDH1A1 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |