Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339251 | 0.82 | MKNK1 (0.38) | SYKMAPKAPK2 | |
| SCHEMBL5337749 | 0.71 | MKNK1 (0.37) | SYKMAPKAPK2 | |
| SCHEMBL5316815 | 0.71 | KDR (0.57) | SYKVCP | |
| SCHEMBL14465953 | 0.70 | FLT1 (0.58) | SYKJAK3JAK1MAPKAPK2VCP | |
| SCHEMBL5336408 | 0.69 | TUBB4A (0.42) | SYKP2RX3JAK3JAK1MAPKAPK2 | |
| SCHEMBL5321701 | 0.69 | ALOX5 (0.52) | SYKVCP | |
| SCHEMBL14466043 | 0.69 | IMPDH2 (0.53) | SYKJAK3JAK1VCP | |
| SCHEMBL5318423 | 0.69 | VCP (0.56) | SYKP2RX3MAPKAPK2VCP | |
| SCHEMBL6315791 | 0.68 | — | — | |
| SCHEMBL5339156 | 0.68 | TUBB4A (0.39) | SYKP2RX3JAK3JAK1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |