Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339251 | 0.89 | MKNK1 (0.38) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5336415 | 0.71 | SYK (0.35) | MAPKAPK2SYK | |
| SCHEMBL14465941 | 0.71 | IMPDH2 (0.61) | ROCK1KDREGFRPIK3CA | |
| SCHEMBL5332616 | 0.70 | MAPKAPK2 (0.45) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5336462 | 0.69 | ROCK2 (0.43) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5337978 | 0.69 | ROCK2 (0.43) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5336680 | 0.69 | IMPDH2 (0.59) | ROCK1KDREGFRPIK3CA | |
| SCHEMBL5333205 | 0.69 | IMPDH2 (0.53) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5336433 | 0.69 | MKNK1 (0.51) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 | |
| SCHEMBL5335613 | 0.69 | CDC7 (0.58) | MKNK1MAPKAPK2ROCK2ROCK1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |