Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533017 | 0.90 | FFAR4 (0.55) | FFAR4MAPTL3MBTL1ALDH1A1GAA | |
| SCHEMBL532880 | 0.87 | FFAR4 (0.56) | FFAR4MAPTTSHRL3MBTL1ALDH1A1 | |
| SCHEMBL533437 | 0.87 | CYTH2 (0.49) | FFAR4MAPTALDH1A1HTTGAA | |
| SCHEMBL533055 | 0.87 | ALDH1A1 (0.45) | FFAR4MAPTTSHRALDH1A1POLB | |
| SCHEMBL532776 | 0.87 | FFAR4 (0.54) | FFAR4MAPTTSHRL3MBTL1ALDH1A1 | |
| SCHEMBL533534 | 0.86 | POLB (0.47) | FFAR4MAPTTSHRPKMMCOLN3 | |
| SCHEMBL533091 | 0.85 | BRPF1 (0.52) | MAPTALDH1A1GAALMNATP53 | |
| SCHEMBL532953 | 0.85 | FFAR4 (0.59) | FFAR4MAPTPKMALDH1A1MEN1 | |
| SCHEMBL533020 | 0.85 | KMT2A (0.51) | FFAR4MAPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL534816 | 0.85 | MAPT (0.41) | FFAR4MAPTPKMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |