Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336462 | 0.98 | ROCK2 (0.43) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5334521 | 0.85 | SYK (0.46) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5340647 | 0.81 | KDR (0.54) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5319685 | 0.81 | IMPDH2 (0.54) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5339924 | 0.81 | MKNK1 (0.57) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5333745 | 0.81 | SYK (0.52) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5336680 | 0.81 | IMPDH2 (0.59) | ROCK1IMPDH2PIK3CAFLT1KDR | |
| SCHEMBL5336433 | 0.81 | MKNK1 (0.51) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5335613 | 0.81 | CDC7 (0.58) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 | |
| SCHEMBL5333205 | 0.81 | IMPDH2 (0.53) | ROCK2ROCK1MKNK1IMPDH2MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |