Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14465943 | 0.97 | SYK (0.53) | SYKKDRROCK2ROCK1TUBB4A | |
| SCHEMBL5333745 | 0.96 | SYK (0.52) | SYKKDRROCK2ROCK1TUBB4A | |
| SCHEMBL5337884 | 0.94 | SYK (0.48) | SYKKDRROCK2ROCK1PIK3CA | |
| SCHEMBL5334521 | 0.89 | SYK (0.46) | SYKKDRROCK2ROCK1PIK3CA | |
| SCHEMBL5319685 | 0.81 | IMPDH2 (0.54) | KDRROCK2ROCK1PIK3CAMKNK1 | |
| SCHEMBL5340647 | 0.81 | KDR (0.54) | KDRROCK2ROCK1MKNK1IMPDH2 | |
| SCHEMBL5339924 | 0.81 | MKNK1 (0.57) | KDRROCK2ROCK1PIK3CAMKNK1 | |
| SCHEMBL5336680 | 0.81 | IMPDH2 (0.59) | KDRROCK1PIK3CAIMPDH2FLT1 | |
| SCHEMBL5336433 | 0.81 | MKNK1 (0.51) | KDRROCK2ROCK1MKNK1IMPDH2 | |
| SCHEMBL5335613 | 0.81 | CDC7 (0.58) | KDRROCK2ROCK1MKNK1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |