Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.57 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.57 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.57 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | VCP | P55072 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333863 | 0.88 | VCP (0.58) | MKNK1PRKAB2LCKSRCFLT1 | |
| SCHEMBL5433991 | 0.87 | RAF1 (0.52) | MKNK1PRKAB2LCKSRCFLT1 | |
| SCHEMBL5350427 | 0.85 | KDR (0.45) | MKNK1PRKAB2LCKSRCFLT1 | |
| SCHEMBL5340647 | 0.84 | KDR (0.54) | MKNK1SRCKDRPRKAA1TNIK | |
| SCHEMBL5319685 | 0.84 | IMPDH2 (0.54) | MKNK1FLT1KDRFLT3TNIK | |
| SCHEMBL5335613 | 0.84 | CDC7 (0.58) | MKNK1FLT1KDRTNIKVCP | |
| SCHEMBL5333205 | 0.84 | IMPDH2 (0.53) | MKNK1FLT1KDRTNIKVCP | |
| SCHEMBL5336680 | 0.84 | IMPDH2 (0.59) | FLT1KDRVCPPIK3CAIMPDH2 | |
| SCHEMBL5336433 | 0.84 | MKNK1 (0.51) | MKNK1FLT1KDRTNIKVCP | |
| SCHEMBL5316809 | 0.84 | NOS1 (0.48) | MKNK1FLT1KDRTNIKVCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |