Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336680 | 0.88 | IMPDH2 (0.59) | IMPDH2GSK3BCDK5DYRK1ADYRK3 | |
| SCHEMBL14465941 | 0.88 | IMPDH2 (0.61) | IMPDH2GSK3BCDK5DYRK1ADYRK3 | |
| SCHEMBL5339924 | 0.84 | MKNK1 (0.57) | IMPDH2MKNK1CDC7KDRFLT1 | |
| SCHEMBL5340647 | 0.84 | KDR (0.54) | IMPDH2GSK3BCDK5DYRK1ADYRK3 | |
| SCHEMBL5333205 | 0.84 | IMPDH2 (0.53) | IMPDH2MKNK1CDC7KDRFLT4 | |
| SCHEMBL5333863 | 0.84 | VCP (0.58) | IMPDH2MKNK1CDC7KDRFLT4 | |
| SCHEMBL5316809 | 0.84 | NOS1 (0.48) | IMPDH2CLK4MKNK1CDC7KDR | |
| SCHEMBL5335613 | 0.84 | CDC7 (0.58) | IMPDH2MKNK1CDC7KDRFLT4 | |
| SCHEMBL5336433 | 0.84 | MKNK1 (0.51) | IMPDH2MKNK1CDC7KDRFLT4 | |
| SCHEMBL5343891 | 0.84 | VCP (0.58) | IMPDH2GSK3BDYRK1ACLK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |