Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | VCP | P55072 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | CLK2 | P49760 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.44 |
| ▸ | PRKCG | P05129 | 2/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343891 | 0.88 | VCP (0.58) | KDRVCPROCK2DYRK1ACLK2 | |
| SCHEMBL5317045 | 0.85 | VCP (0.63) | KDRVCPROCK2DYRK1AROCK1 | |
| SCHEMBL5339924 | 0.84 | MKNK1 (0.57) | KDRVCPROCK2ROCK1PRKAA1 | |
| SCHEMBL5319685 | 0.84 | IMPDH2 (0.54) | KDRVCPROCK2DYRK1ACLK2 | |
| SCHEMBL5333205 | 0.84 | IMPDH2 (0.53) | KDRVCPROCK2ROCK1MKNK1 | |
| SCHEMBL5336433 | 0.84 | MKNK1 (0.51) | KDRVCPROCK2ROCK1SIRT7 | |
| SCHEMBL5336680 | 0.84 | IMPDH2 (0.59) | KDRVCPDYRK1ACLK2ROCK1 | |
| SCHEMBL5335613 | 0.84 | CDC7 (0.58) | KDRMAOBVCPROCK2ROCK1 | |
| SCHEMBL5316809 | 0.84 | NOS1 (0.48) | KDRVCPROCK2ROCK1CLK4 | |
| SCHEMBL5333863 | 0.84 | VCP (0.58) | KDRVCPROCK2ROCK1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |