Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5270761 | 0.92 | PPARD (0.33) | SCN8ASCN10APPARDMAPTACACB | |
| SCHEMBL5509080 | 0.81 | PTPN5 (0.37) | GPR35SCN8ASCN10APTPN5PPARD | |
| SCHEMBL5269766 | 0.77 | TOP2A (0.38) | SCN8ASCN10APTPN5PPARDMCL1 | |
| SCHEMBL5271483 | 0.77 | RORC (0.36) | MAPTKMT2AACACBACACAKDM4E | |
| SCHEMBL5340171 | 0.76 | MAPT (0.38) | PTPN5MAPTCLK1KMT2AMCL1 | |
| SCHEMBL5266914 | 0.75 | MAPT (0.41) | PTPN5PPARDMAPTKMT2AKDM4E | |
| SCHEMBL5271428 | 0.75 | MAPT (0.41) | PTPN5PPARDMAPTKMT2AKDM4E | |
| SCHEMBL5270354 | 0.75 | MAPT (0.49) | MAPTKMT2A | |
| SCHEMBL5339900 | 0.75 | BRD4 (0.40) | KMT2AACACBACACABRD4 | |
| SCHEMBL5268151 | 0.74 | MAPT (0.36) | SCN8ASCN10APTPN5PPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844013-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006077364-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |