Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8679261 | 0.81 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| SCHEMBL51292 | 0.81 | — | — | |
| Water SCHEMBL11323077 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL9715834 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28103727 | 0.78 | KCNN4 (0.31) | — | |
| Tromethamine SCHEMBL670237 | 0.76 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9933746 | 0.76 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL571834 | 0.74 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1019777 | 0.74 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1115948 | 0.74 | MEN1 (0.56) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415461-B1 | Stabilization of interleukin 6 in serum based solutions | ROCHE DIAGNOSTICS GMBH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2415461-A1 | Stabilization of interleukin 6 in serum based solutions | Roche Diagnostics GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |