Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8679261 | 0.82 | MEN1 (0.59) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL571834 | 0.81 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL1019777 | 0.81 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL1358336 | 0.78 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3705445 | 0.78 | MEN1 (0.71) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL28216031 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL7193959 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Alcohol SCHEMBL9167887 | 0.77 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.77 | — | — | |
| Tromethamine SCHEMBL975 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465607-B1 | SYNTHESIS OF SEQUESTRATION RESINS FOR WATER TREATMENT IN LIGHT WATER REACTORS | ELECTRIC POWER RES INSTITUTE INC (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-2466593-B1 | Light water reactor primary coolant radioactivity cleanup | ELECTRIC POWER RES INSTITUTE INC (US) | 2018-09-05 | — | — | EP | disclosed |
| EP-2466592-B1 | Capture, removal, and disposal of radioactive species in an aqueous solution | ELECTRIC POWER RES INSTITUTE INC (US) | 2018-03-14 | — | — | EP | disclosed |
| US-9589690-B2 | Light water reactor primary coolant activity cleanup | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9214248-B2 | Capture and removal of radioactive species from an aqueous solution | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-8975340-B2 | Synthesis of sequestration resins for water treatment in light water reactors | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20120183115-A1 | LIGHT WATER REACTOR PRIMARY COOLANT ACTIVITY CLEANUP | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184796-A1 | CAPTURE, REMOVAL, AND STORAGE OF RADIOACTIVE SPECIES IN AN AQUEOUS SOLUTION | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120157556-A1 | SYNTHESIS OF SEQUESTRATION RESINS FOR WATER TREATMENT IN LIGHT WATER REACTORS | ELECTRIC POWER RESEARCH INSTITUTE, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| EP-2465607-A2 | Synthesis of sequestration resins for water treatment in light water reactors | Electric Power Research Institute, Inc. (US) | 2012-06-20 | — | — | EP | disclosed |
| EP-2466592-A1 | Capture, removal, and disposal of radioactive species in an aqueous solution | Electric Power Research Institute, Inc. (US) | 2012-06-20 | — | — | EP | disclosed |
| EP-2466593-A1 | Light water reactor primary coolant radioactivity cleanup | Electric Power Research Institute, Inc. (US) | 2012-06-20 | — | — | EP | disclosed |