Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL1115948 | 0.97 | MEN1 (0.56) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7351641 | 0.82 | MEN1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2862081 | 0.81 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL466420 | 0.79 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL10651632 | 0.78 | MEN1 (0.71) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL561096 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28216031 | 0.77 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL975 | 0.77 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566506-B1 | VACCINE COMPOSITION FOR PREVENTING OR TREATING LEISHMANIASES | VIRBAC (FR) | 2016-07-06 | — | — | EP | claimed |
| EP-2605780-B1 | CONCENTRATE FOR MEDICAL SOLUTIONS, PRODUCTION THEREOF AND USE THEREOF IN DIALYSIS | FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (DE) | 2019-10-23 | — | — | EP | disclosed |
| WO-2016133913-A1 | FLUORESCENTLY LABELED MOLECULES CONTAINING MODIFIED TRYPTOPHAN | SEED RESEARCH AND DEVELOPMENT LLC (US) | 2016-08-25 | — | — | WO | disclosed |
| WO-2016090169-A1 | INTRACELLULAR CASPASE PROBES FOR DETECTION OF APOPTOSIS AND INFLAMMATION AND KITS CONTAINING SUCH PROBES | SEED RESEARCH AND DEVELOPMENT LLC (US) | 2016-06-09 | — | — | WO | disclosed |
| EP-2605780-A1 | CONCENTRATE FOR MEDICAL SOLUTIONS, PRODUCTION THEREOF AND USE THEREOF IN DIALYSIS | Fresenius Medical Care Deutschland GmbH (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2013053694-A1 | MONOCLONAL ANTI-IDIOTYPE ANTIBODY GANGLIDIOMAB | Ernst-Moritz-Arndt-Universität Greifswald (DE) | 2013-04-18 | — | — | WO | disclosed |
| WO-2012022775-A1 | CONCENTRATE FOR MEDICAL SOLUTIONS, PRODUCTION THEREOF AND USE THEREOF IN DIALYSIS | FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |
| EP-1440158-A1 | METHOD FOR THE PRODUCTION OF (R)- AND (S)-8-CHLORO-6-HYDROXY-OCTANIC ACID ALKYL ESTERS BY ENZYMATIC REDUCTION | VIATRIS GmbH & Co. KG (DE) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003035885-A1 | METHOD FOR THE PRODUCTION OF (R)- AND (S)-8-CHLORO-6-HYDROXY-OCTANIC ACID ALKYL ESTERS BY ENZYMATIC REDUCTION | VIATRIS GMBH & CO. KG (DE) | 2003-05-01 | — | — | WO | disclosed |
| EP-1194769-A1 | DEVICE FOR PREPARING SAMPLES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| EP-0815072-B1 | RADIOGRAPHIC CONTRASTING AGENT FOR COMPUTERISED TOMOGRAPHY AND UROGRAPHY | SCHERING AG (DE) | 2000-06-28 | — | — | EP | disclosed |
| EP-0815072-A1 | RADIOGRAPHIC CONTRASTING AGENT FOR COMPUTERISED TOMOGRAPHY AND UROGRAPHY | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028415-A1 | RADIOGRAPHIC CONTRASTING AGENT FOR COMPUTERISED TOMOGRAPHY AND UROGRAPHY | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-19 | — | — | WO | disclosed |
| EP-0496822-B1 | CARRIER AND ITS USE IN NUCLEIC ACID CHROMATOGRAPHIC SEPARATION | MACHEREY NAGEL & CO CHEM (DE) | 1993-10-20 | — | — | EP | disclosed |
| EP-0496822-A1 | CARRIER AND ITS USE IN NUCLEIC ACID CHROMATOGRAPHIC SEPARATION. | MACHEREY NAGEL GMBH & CO KG (DE) | 1992-08-05 | — | — | EP | disclosed |
| WO-1991005606-A1 | CARRIER AND ITS USE IN NUCLEIC ACID CHROMATOGRAPHIC SEPARATION | MACHEREY-NAGEL & CO. (DE) | 1991-05-02 | — | — | WO | disclosed |
| EP-0373335-A2 | Serine protease inhibitor proteins, medicaments containing them, DNA sequences coding for these proteins and methods for producing these proteins, medicaments and DNA sequences | Grünenthal GmbH (DE) | 1990-06-20 | — | — | EP | disclosed |
| EP-0330725-A1 | Preparation and expression of DNA sequences coding for proteins having the biological properties of cystatin C | Grünenthal GmbH (DE) | 1989-09-06 | — | — | EP | disclosed |
| EP-0303155-A2 | Method to identify nucleic-acid sequences | MERCK PATENT GmbH (DE) | 1989-02-15 | — | — | EP | disclosed |
| EP-0214548-A2 | DNA sequences, recombinant DNA molecules and process for the preparation of the enzyme mutarotase of Acinetobacter calcoaceticus | MERCK PATENT GmbH (DE) | 1987-03-18 | — | — | EP | disclosed |