Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25706938 | 0.89 | HTR2A (0.65) | SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL31307673 | 0.89 | HTR2A (0.65) | SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL16210197 | 0.85 | KMT2A (0.68) | SMN1; SMN2POLBKMT2ALMNARECQL | |
| SCHEMBL14811705 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2POLBKMT2ALMNARECQL | |
| SCHEMBL11747110 | 0.81 | MTNR1A (0.59) | KMT2ALMNAMTNR1AMTNR1BHSD17B10 | |
| SCHEMBL11304565 | 0.79 | MTNR1A (0.66) | SMN1; SMN2KMT2AMTNR1AMTNR1BHSD17B10 | |
| SCHEMBL6555821 | 0.79 | MTNR1B (0.64) | KMT2AMTNR1AMTNR1BHSD17B10TP53 | |
| SCHEMBL25238411 | 0.79 | HTR2A (0.63) | MTNR1AMTNR1B | |
| SCHEMBL25424120 | 0.78 | HTR2A (0.67) | SMN1; SMN2POLBKMT2A | |
| SCHEMBL2921658 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBKMT2ALMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-56128756-A | — | — | None | — | — | JP | disclosed |
| CN-113816891-A | Synthesis method of 5, 6-dihydroxyindole and derivatives thereof | 河南省科学院化学研究所有限公司 | 2021-12-21 | — | — | CN | disclosed |
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |
| JP-S56128756-A | PREPARATION OF INDOLE DERIVATIVE | SENDAI FUKUSOKAN KAGAKU KENKYUSHO | 1981-10-08 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | SMN1; SMN2 4604/4885POLB 1555/4885KMT2A 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.