Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431179 | 1.00 | ROCK2 (0.48) | ROCK2ROCK1MAPK1BRAFSYK | |
| SCHEMBL5320011 | 1.00 | ROCK2 (0.48) | ROCK2ROCK1MAPK1BRAFSYK | |
| SCHEMBL5318853 | 0.87 | ROCK2 (0.62) | ROCK2ROCK1MAPK1KDR | |
| SCHEMBL14466075 | 0.85 | ROCK2 (0.62) | ROCK2SYKKDR | |
| SCHEMBL5342613 | 0.82 | VCP (0.50) | ROCK2ROCK1MAPK1SYKKDR | |
| SCHEMBL5333863 | 0.81 | VCP (0.58) | ROCK2ROCK1KDR | |
| SCHEMBL5333205 | 0.81 | IMPDH2 (0.53) | ROCK2ROCK1KDR | |
| SCHEMBL5319078 | 0.81 | ROCK2 (0.52) | ROCK2ROCK1KDR | |
| SCHEMBL5336680 | 0.79 | IMPDH2 (0.59) | ROCK1KDR | |
| SCHEMBL5335613 | 0.79 | CDC7 (0.58) | ROCK2ROCK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |